miRNA regulation of Sdf1 chemokine signaling provides genetic robustness to germ cell migration
نویسندگان
چکیده
منابع مشابه
The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival.
In mouse embryos, germ cells arise during gastrulation and migrate to the early gonad. First, they emerge from the primitive streak into the region of the endoderm that forms the hindgut. Later in development, a second phase of migration takes place in which they migrate out of the gut to the genital ridges. There, they co-assemble with somatic cells to form the gonad. In vitro studies in the m...
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ژورنال
عنوان ژورنال: Nature Genetics
سال: 2011
ISSN: 1061-4036,1546-1718
DOI: 10.1038/ng.758